Effect of chronic YM-358, a nonpeptide AT<sub>1</sub> receptor antagonist, on diurnal rhythm of blood pressure, heart rate and locomotor activity in stroke-prone spontaneously hypertensive rats
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چکیده
منابع مشابه
Stroke-Prone Spontaneously Hypertensive Rats
Background and Purpose We examined metabolic and functional changes when forebrain ischemia was induced in strokeprone spontaneously hypertensive rats by bilateral carotid artery occlusion. In addition, the protective effect of clentiazem was evaluated in this model. Methods Rats were anesthetized with urethane. Cerebral blood flow was measured with a laser Doppler fkrwmeter. Cerebral high-ener...
متن کاملHypertensive Rats, Independently of Blood Pressure Pioglitazone Exerts Protective Effects Against Stroke in Stroke-Prone Spontaneously
Taishi Nakamura, Eiichiro Yamamoto, Keiichiro Kataoka, Takuro Yamashita, Yoshiko Hypertensive Rats, Independently of Blood Pressure Pioglitazone Exerts Protective Effects Against Stroke in Stroke-Prone Spontaneously Print ISSN: 0039-2499. Online ISSN: 1524-4628 Copyright © 2007 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville ...
متن کاملPioglitazone exerts protective effects against stroke in stroke-prone spontaneously hypertensive rats, independently of blood pressure.
BACKGROUND AND PURPOSE Very recent subgroup analysis from the PROspective pioglitAzone Clinical Trial In macroVascular Events has shown that pioglitazone reduces the risk of recurrent stroke in type 2 diabetic patients. However, the underlying mechanism of stroke prevention by pioglitazone is unknown. Our aim was to examine the effect of pioglitazone on hypertension-based stroke in rats. METH...
متن کامل: the effect of sericin levels (silk glue protein) on rate of in vitro maturation, fertilization and culture of sheep oocytes
هدف از آزمایش اول بررسی اثر سطوح مختلف سریسین [0 (control), 0.1, 0.5, 1.0, 2.5 %] افزوده شده به محیط , ivm بر cumulus cell expansion، بلوغ هسته و توسعه متوالی جنین، در گوسفندان نژاد سنجابی در فصل تولید مثلی می باشد. از سرگیری میوز به وسیله خارج شدن اولین پولار بادی اندازه گیری و هم چنین درصد رسیدن جنین های دو سلولی به مرحله کلیواژ و بلاستوسیت نیز به عنوان نشانه ای از میزان شایستگی توسعه اولیه ج...
Cerebral plasminogen activator activity in spontaneously hypertensive stroke-prone rats.
BACKGROUND AND PURPOSE In the spontaneously hypertensive stroke-prone rat, it is unclear whether plasminogen activator plays a role in the development of stroke. The present study was undertaken to investigate brain levels of plasminogen activator activity in spontaneously hypertensive stroke-prone rats and Wistar-Kyoto rats. METHODS Plasminogen activator was purified from the brains of rats ...
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ژورنال
عنوان ژورنال: Japanese Heart Journal
سال: 1996
ISSN: 0021-4868,1348-673X
DOI: 10.1536/ihj.37.538